75000 - Document - Cover Page
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75010 - Statement - CONSOLIDATED BALANCE SHEETS
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75020 - Disclosure - Debt - Summary of Long-term Debt Balance (Detail) 2
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75030 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)
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75040 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS
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75050 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)
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75060 - Statement - CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (DEFICIT)
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75070 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS
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995455 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995465 - Disclosure - Nature of the Business
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995475 - Disclosure - Summary of Significant Accounting Policies
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995485 - Disclosure - Accounting for the Merger
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995495 - Disclosure - Sale of Asset
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995505 - Disclosure - Short-Term Investments
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995515 - Disclosure - Fair Value Measurements
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995525 - Disclosure - Investment in Equity Securities
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995535 - Disclosure - Property and Equipment, Net
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995545 - Disclosure - Prepaid Expenses, Other Current Assets and Other Noncurrent Assets
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995555 - Disclosure - Accrued Expenses and Other Current Liabilities
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995565 - Disclosure - Commitments and Contingencies
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995575 - Disclosure - Debt
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995585 - Disclosure - Convertible Preferred Stock
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995595 - Disclosure - Common Stock
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995605 - Disclosure - Stock-Based Compensation
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995615 - Disclosure - Agreements with Horizon
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995625 - Disclosure - Related Party Transactions
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995635 - Disclosure - Defined Contribution Plan
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995645 - Disclosure - Income Taxes
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995655 - Disclosure - Net Income (Loss) per Share
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995665 - Disclosure - Segment Reporting
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995675 - Disclosure - Subsequent Events
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995685 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995695 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995705 - Disclosure - Accounting for the Merger (Tables)
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995715 - Disclosure - Short-Term Investments (Tables)
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995725 - Disclosure - Fair Value Measurements (Tables)
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995735 - Disclosure - Property and Equipment, Net (Tables)
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995745 - Disclosure - Prepaid Expenses, Other Current Assets and Other Noncurrent Assets (Tables)
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995755 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)
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995765 - Disclosure - Commitments and Contingencies (Tables)
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995775 - Disclosure - Debt (Tables)
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995785 - Disclosure - Common Stock (Tables)
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995795 - Disclosure - Stock-Based Compensation (Tables)
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995805 - Disclosure - Agreements with Horizon (Tables)
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995815 - Disclosure - Income Taxes (Tables)
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995825 - Disclosure - Net Income (Loss) per Share (Tables)
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995835 - Disclosure - Segment Reporting (Tables)
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995845 - Disclosure - Nature of the Business - Additional Information (Detail)
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995855 - Disclosure - Summary of Significant Accounting Policies - Summary of Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents (Details)
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995865 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail)
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995875 - Disclosure - Summary of Significant Accounting Policies - Estimated Useful Life of Assets (Detail)
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995885 - Disclosure - Accounting for the Merger - Summary of Recapitalization of Assets and Liabilities (Details)
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995895 - Disclosure - Accounting for the Merger - Additional Information (Details)
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995905 - Disclosure - Sale of Asset (Additional Information) (Details)
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995915 - Disclosure - Short-Term Investments - Summary of Short-Term Investments (Details)
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995925 - Disclosure - Short-Term Investments - Additional Information (Details)
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995935 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Detail)
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995945 - Disclosure - Fair Value Measurements - Summary of Fair Value Measurement Significant Inputs (Detail)
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995955 - Disclosure - Fair Value Measurements - Additional Information (Detail)
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995965 - Disclosure - Investment in Equity Securities - Additional Information (Details)
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995975 - Disclosure - Property and Equipment, Net - Schedule of Property Plant and Equipment (Detail)
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995985 - Disclosure - Property and Equipment, Net - Additional Information (Detail)
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995995 - Disclosure - Prepaid Expenses, Other Current Assets and Other Noncurrent Assets - Summary of Prepaid Expenses and Other Current Assets (Detail)
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996005 - Disclosure - Prepaid Expenses, Other Current Assets and Other Noncurrent Assets (Additional Information) (Details)
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996015 - Disclosure - Prepaid Expenses, Other Current Assets and Other Noncurrent Assets - Summary of Prepaid Expenses and Other Noncurrent Assets (Detail)
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996025 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail)
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996035 - Disclosure - Commitments and Contingencies Summary of Amounts Reported in the Balance Sheet in Respect of Operating Lease Assets and Corresponding Liabilities (Detail)
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996045 - Disclosure - Commitments and Contingencies - Schedule of Operating Lease Cost and Variable Lease Costs and Sub Lease Income (Detail)
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996055 - Disclosure - Commitments and Contingencies - Schedule of Maturities of Operating Lease Liabilities (Detail)
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996065 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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996075 - Disclosure - Debt - Additional Information (Detail)
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996085 - Disclosure - Debt - Summary of Long-term Debt Balance (Detail)
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996095 - Disclosure - Convertible Preferred Stock - Additional Information (Detail)
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996105 - Disclosure - Common Stock - Schedule of Shares of Common Stock for Future Issuance (Detail)
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996115 - Disclosure - Common Stock - Additional Information (Detail)
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996125 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Detail)
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996135 - Disclosure - Stock-Based Compensation - Company's RSU Activity (Details)
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996145 - Disclosure - Stock-Based Compensation - Summary of Assumptions Used to Value Stock Options Granted (Detail)
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996155 - Disclosure - Stock-Based Compensation - Summary of Stock Based Compensation Expense (Detail)
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996165 - Disclosure - Stock-Based Compensation - Additional Information (Detail)
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996175 - Disclosure - Agreements with Horizon - Additional Information (Detail)
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996185 - Disclosure - Agreements with Horizon - Summary of the Transaction Price Allocated to Each Performance Obligation (Detail)
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996195 - Disclosure - Related Party Transactions - Additional Information (Detail)
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996205 - Disclosure - Income Taxes - Additional Information (Detail)
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996215 - Disclosure - Income Taxes - Schedule of Income (Loss) Before Provision For Income Taxes (Details)
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996225 - Disclosure - Income Taxes - Schedule of Components of Income Tax Expense (Details)
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996235 - Disclosure - Income Taxes - Schedule Income Taxes Paid (Details)
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996245 - Disclosure - Income Taxes - Schedule of Reconciliation Federal Statutory Income Tax Rate to Effective Income Tax Rate (Details)
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996255 - Disclosure - Income Taxes - Schedule of Components of Deferred Income Taxes (Details)
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996265 - Disclosure - Income Taxes - Summary of Changes in The Valuation Allowance (Details)
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996275 - Disclosure - Net Income (Loss) per Share - Summary of calculation of diluted net income (loss) per share, the numerator is adjusted for any changes (Details)
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996285 - Disclosure - Net Income (Loss) per Share - Summary of Computation of Diluted Net Loss Per Share Attributable to Common Stockholders (Detail)
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996295 - Disclosure - Net Income (Loss) per Share - Additional Information (Detail)
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996305 - Disclosure - Segment Reporting (Additional Information) (Details)
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996315 - Disclosure - Segment Reporting - Summary of the Company's segment expenses (Details)
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996325 - Disclosure - Subsequent Events (Additional Information) (Details)
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Common Stock, Value, Subscriptions
Common stock, aggregate purchase price
Homology.
Homology [Member]
Homology
Commercial milestone payment payable.
Commercial Milestone Payment Payable
Commercial milestone payment payable
Other Research and Development Expense
Indirect research and development expense
Other Research And Development Expense
Segments [Domain]
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Accounting policies.
Accounting Policies [Line Items]
Milestones Payment Receivable
Milestones Payment Receivable
Milestones payment
Entity Incorporation, State or Country Code
Annual rent operating lease aggregate after increase.
Annual rent operating lease aggregate after increase
Annual Rent Operating lease Aggregate After Increase
Preferred Stock, Shares Issued
Preferred stock shares issued
Statement of Financial Position Location, Balance [Domain]
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Tax credits:
Event.
Event [Axis]
Event [Axis]
Increase (Decrease) in Accounts Payable
Accounts payable
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosure of non-cash operating, investing and financing activities:
Long-Term Debt, Excluding Current Maturities
Long-term debt, net
Business Combination, Contingent Consideration, Change in Contingent Consideration, Liability, Increase (Decrease)
Issuance of CVR at fair value
Plan Name [Axis]
Entity Current Reporting Status
Nature of business.
Nature Of Business [Line Items]
Operating Expenses [Abstract]
Operating expenses:
Fair Value, Inputs, Level 2 [Member]
Significant Other Observable Inputs (Level 2) [Member]
Total deferred tax assets, net of valuation allowance
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Components of in process research and development expenses.
Components Of In Process Research And Development Expenses [Axis]
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Common Stock, Shares Authorized
Common stock, shares authorized
Temporary Equity, Par or Stated Value Per Share
Preferred stock par value per share
Product and Service [Axis]
Sale of Asset Guaranteed Upfront
Sale of asset guaranteed upfront.
Sale of asset guaranteed upfront
Upon receipt of waiver of milestone conditions.
Upon Receipt Of Waiver Of Milestone Conditions [Member]
Upon Receipt Of Waiver Of Milestone Conditions [Member]
Document Fiscal Period Focus
Entity Shell Company
Temporary Equity, Shares Outstanding
Ending balance, Shares
Beginning balance, Shares
Preferred stock shares outsstanding
Series A One Convertible Preferred Stock.
Series A One Convertible Preferred Stock [Member]
Series A-1 convertible preferred stock [Member]
Series A-1 convertible preferred stock [Member]
Segment Reporting, Policy [Policy Text Block]
Segment Information
Cash and Cash Equivalent
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash equivalents
Weighted Average Number of Shares Outstanding Reconciliation [Abstract]
Denominator:
Tranche.
Tranche [Domain]
Valuation Allowance [Line Items]
Stock Issued During Period, Shares, Conversion of Units
Issuance of common stock for conversion of convertible notes, Shares
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued
Common stock shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Short-Term Debt [Table]
Asset Class [Domain]
Operating right-of-use asset
Operating right-of-use asset
Deferred Tax Liabilities, Other Finite-Lived Assets
Statement [Table]
Proceeds from Issuance of Redeemable Convertible Preferred Stock
Proceeds from redeemable convertible preferred stock
Non-Rule 10b5-1 Arr Modified [Flag]
Non-Rule 10b5-1 Arrangement Modified [Flag]
Non-Rule 10b5-1 Arrangement Modified
Changes Measurement [Member]
Change in fair value
Share-Based Payment Arrangement, Disclosure [Abstract]
Deferred Tax Asset, Valuation Allowance [Table]
Research and Development Asset Acquired in Transaction Other than Business Combination or Joint Venture Formation, Writeoff
In process research and development expense recognized
Horizon collaboration agreement.
Horizon Collaboration Agreement [Member]
Horizon collaboration agreement
Temporary Equity.
Temporary Equity [Member]
Statement [Line Items]
Business Combination [Domain]
Percentage of outstanding debt to be maintained with the lender by way of cash.
Percentage Of Outstanding Debt To Be Maintained With The Lender By Way Of Cash
Percentage of outstanding debt to be maintained with the lender by way of cash
Warrant [Member]
Shares reserved for warrants [Member]
Warrants to purchase common stock
Entity Filer Category
Upon the conversion of authorized series a1 redeemable convertible preferred stock.
Upon The Conversion Of Authorized Series A1 Redeemable Convertible Preferred Stock [Member]
Shares reserved upon the conversion of authorized Series A-1 preferred stock [Member]
Liabilities and Equity
Total liabilities and stockholders' equity (deficit)
Debt Instrument [Line Items]
Payables and Accruals [Abstract]
Long-Term Debt, Current Maturities
Less current portion
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted- Average Exercise Price, Exercisable
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Severance Costs
Payment Related to Severance Cost
Lease expiration date year and month.
Lease Expiration Date Year And Month
Operating lease expiration year and month
Total change in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Valuation allowance period increase
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Other segment items [Member]
Other segment items
Valuation allowance
Beginning balance
Ending balance
Beginning balance
Deferred Tax Assets, Valuation Allowance
Less: Valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
U.S. statutory tax rate
Federal income tax expense at statutory rate
Subsequent Event [Line Items]
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Effective Income Tax Rate Reconciliation, Percent, Total
Effective income tax rate
Effective income tax rate
Shares reserved for stock option exercises [Member]
Convertible Debt Securities [Member]
Shares reserved upon the conversion of the convertible notes [Member]
Income Tax Jurisdiction [Axis]
Proceeds from Convertible Debt
Proceeds from issuance of convertible debt
Proceeds from convertible debt
Cash Consideration.
Cash Consideration [Member]
Geographical [Domain]
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Defined Contribution Plan [Abstract]
Warrants issued to silicon valley bank.
Warrants Issued To Silicon Valley Bank [Member]
Warrants Issued To Silicon Valley Bank [Member]
US Statutory Tax Rate
US Statutory Tax Rate
U.S. statutory tax rate
Loss on impairment of equity investment
Loss on impairment of equity investment
Loss on impairment of equity investment
Related Party [Member]
Related Party
Defined Contribution Plan [Text Block]
Defined Contribution Plan
Legacy Q32 [Member]
Legacy Q32 [Member]
Legacy Q32
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property Plant and Equipment [Line Items]
Schedule of Cash and Cash Equivalents [Table Text Block]
Summary of Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Foreign exchange contracts option contracts and other foreign exchange hedging arrangements.
Foreign Exchange Contracts Option Contracts And Other Foreign Exchange Hedging Arrangements [Member]
Foreign exchange contracts & other forign heding arrangements [Member]
Before First Of July Two Thousand And Twenty Five [Member]
Before First Of July Two Thousand And Twenty Five [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of Shares, Granted
Share based compensation by share based award options granted during the period shares
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of calculation of diluted net income (loss) per share, the numerator is adjusted for any changes
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Nontaxable or nondeductible items
Cumulative Changes Ownership Interest
Cumulative Changes Ownership Interest
Cumulative Changes Ownership Interest
Company's Effective Tax Rate
Company's Effective Tax Rate
Company's effective tax rate
Investment, Name [Axis]
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Net income (loss) per share-basic
Net income (loss) per share- basic
Income tax disclosure.
Income Tax Disclosure [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Shares, Outstanding at Ending Balance
Number of Shares, Outstanding at Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value
Weighted- Average Exercise Price, Vested
Face value of debt instrument that may be contingently borrowed.
Face Value of Debt Instrument That May Be Contingently Borrowed
Face value of debt instrument that may be contingently borrowed
Debt, Policy [Policy Text Block]
Debt and Warrant Issuance Costs
Liabilities, Current
Total current liabilities
Sublease aggregate base rent obligation.
Sublease Aggregate Base Rent Obligation
Sublease aggregate base rent obligation
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Lessee, Operating Lease, Liability, to be Paid, Year Five
2030
Federal
Income Tax Paid, Federal, after Refund Received
Income Tax Paid, Federal, after Refund Received, Total
Federal tax jurisdiction [Member]
Domestic federal income taxes [Member]
Domestic Tax Jurisdiction [Member]
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Tax credits:
Parent company [Member]
Parent Company [Member]
Effective Income Tax Rate Reconciliation [Table]
Agreement.
Agreement [Domain]
Agreement [Domain]
Equity, Attributable to Parent [Abstract]
Stockholders' equity (deficit):
Entity Small Business
Line of Credit Facility, Commitment Fee Amount
Line of credit facility commitment fee amount
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Total deferred
Total deferred
Total deferred
Preferred Stock [Member]
Preferred Stock [Member]
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Shares, Forfeited
Consulting and advisory agreements.
Consulting And Advisory Agreements [Member]
Consulting and Advisory Agreements
Offering price
Sale of Stock, Price Per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of options exercised
Current Foreign
Current Foreign Tax Expense (Benefit)
Tranche.
Tranche [Axis]
Subsequent Events, Policy [Policy Text Block]
Subsequent Event Considerations
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Waltham massauchets.
Waltham Massauchets [Member]
Waltham Massauchets [Member]
Material right for the purchase of ADX nine hundred and fourteen.
Material Right For The Purchase Of ADX Nine Hundred And Fourteen [Member]
Material right for the purchase of ADX-914
Contract with Customer, Liability
Amount retained
Debt Instrument, Payment Terms
Debt instrument terms of payment
Amendment Flag
Product and Service [Domain]
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Personnel Related Costs Excluding Stock Based Compensation
Personnel Related Costs Excluding Stock Based Compensation
Personnel-related costs (excluding stock-based compensation)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Class of warrants or rights number of securities covered by warrants or rights
Upfront payment made.
Upfront Payment Made
Upfront payment made
Liabilities, convertible preferred stock and stockholders' equity
Liabilities and Equity [Abstract]
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Increase (Decrease) in Operating Lease Liability
Operating lease liability
components of in process research and development expenses.
Components Of In Process Research And Development Expenses [Domain]
Commitment and contingencies.
Commitment And Contingencies [Table]
Change In Fair Value Of Equity Investment
Change In Fair Value Of Equity Investment
Change in fair value of CVR liability
Measurement input probability of each scenario member.
Measurement Input Probability Of Each Scenario [Member]
Probability of each scenario [Member]
Common Stock [Member]
Common Stock [Member]
Cybersecurity Risk Role of Management [Text Block]
Tax Credit Carryforward, Amount
Research and development tax credit carryforwards
Gain On Convertible Notes
Gain On Convertible Notes
Gain on conversion of convertible notes
Gain on convertible notes
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted- Average Exercise Price, Granted
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation
Other Operating Income (Expense), Net
Other income (expense), net
Tranche two milestone.
Tranche Two Milestone [Member]
Tranche Two [Member]
Debt Instrument, Interest Rate, Effective Percentage
Debt instrument effective rate of interest percentage
Portion at Fair Value Measurement [Member] [Default]
Portion at Fair Value Measurement [Member]
Entity Address, Address Line One
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Assumptions Used to Value Stock Options Granted
Patents costs.
Patents Costs [Policy Text Block]
Patent Costs
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger
Percentage of Purchase Price of Convertible notes to Common stock
Earnings Per Share [Abstract]
Income Tax, Policy [Policy Text Block]
Income Taxes
Temporary Equity, Carrying Amount, Attributable to Parent
Total convertible preferred stock
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Transactions
Bempikibart [Member]
Bempikibart [Member]
Bempikibart [Member]
Statement of Financial Position Location, Balance [Axis]
Operating Lease, Right-of-Use Asset
Right-of-use asset, operating leases
Operating lease right-of-use assets
Total deferred tax assets
Deferred Tax Assets, Gross, Total
Net deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Share Based Compensation Arrangement By Share Based Payment Award Stock Offering Period
Share Based Compensation Arrangement By Share Based Payment Award Stock Offering Period
Common stock offering period
Class of Warrant or Right [Axis]
Document Type
Reserved For Future Issuance Under Two Thousand And Twenty Four Stock Plan Member
Reserved For Future Issuance Under Two Thousand And Twenty Four Stock Plan [Member]
Shares reserved for future issuance under the 2024 Stock Incentive Plan
Income Taxes Paid, Net
Income Taxes Paid
Total cash paid during the period for income taxes
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Entity Central Index Key
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Prime Rate [Member]
Prime Rate [Member]
Annual Net Sales Threshold Trigger
Annual Net Sales Threshold Trigger
Annual net sales threshold trigger
Proceeds from Sales of Business, Affiliate and Productive Assets
Amount received on sales of asset
Deposit transferred to a payment processor to pay out investigator site fees
Deposit Transferred to Payout Investigator Site Fees
Deposit Transferred to Payout Investigator Site Fees
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation
Net increase (decrease) in cash, cash equivalents, restricted cash and restricted cash equivalents
Commitment and contingencies.
Commitment And Contingencies [Line Items]
Subsequent Event Type [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Options to purchase common stock
APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition
Stock-based compensation expense
Incentive from Lessor
Lessee tenant improvement allowance
Common Stock, Par or Stated Value Per Share
Common stock, par value per share
Disclosure in tabular form of common stock shares reserved for future issuance.
Disclosure In Tabular Form Of Common Stock Shares Reserved For Future Issuance [Line Items]
Disclosure in Tabular form of Common Stock Shares Reserved for Future Issuance [Line Items]
Security Deposit
Security deposit
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Other comprehensive loss
Total other comprehensive gain (loss)
Principal payments on venture debt
Payment On Venture Debt
Payment On Venture Debt
Series B Convertible Preferred Stock.
Series B Convertible Preferred Stock [Member]
Series B convertible preferred stock [Member]
Series B convertible preferred stock [Member]
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash lease expense
Convertible debt agreement.
Convertible Debt Agreement [Member]
Convertible Debt Agreement [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected stock price volatility range, maximum
Asset Acquisition, Contingent Consideration, Liability
Contingent payment liability
Asset Acquisition, Contingent Consideration, Liability, Total
CVR liability
Debt Securities, Available-for-Sale, Amortized Cost
Short-term investments, Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost, Total
Foreign Tax Jurisdiction, Other [Member]
Other foreign jurisdictions [Member]
Debt Securities, Available-for-Sale
Short-term investments, Fair Value
Debt Securities, Available-for-Sale, Total
Series a one redeemable convertible preferred stock.
Series A One Redeemable Convertible Preferred Stock [Member]
Series A One Redeemable Convertible Preferred Stock [Member]
Document Financial Statement Error Correction [Flag]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Issuance of common stock from option exercises, Shares
Number of Shares, Exercised
Debt Disclosure [Abstract]
Received advance payment
Received Advance Payment
Received Advance Payment
Facilities, IT and insurance [Member]
Facilities, IT and insurance
Estimate of Fair Value Measurement [Member]
Fair Value [Member]
Accrued Liabilities, Current
Total accrued expenses and other current liabilities
Total accrued expenses and other current liabilities
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Achievement of specified milestones.
Achievement Of Specified Milestones [Member]
Achievement Of Specified Milestones [Member]
Summary of estimated useful life of assets.
Summary Of Estimated Useful Life Of Assets [Table Text Block]
Summary of Estimated Useful Life of Assets
Restricted Cash and Cash Equivalent, Noncurrent
Restricted cash and restricted cash equivalents
Restricted Cash and Cash Equivalents, Noncurrent, Total
Restricted cash equivalents
Convertible Notes Payable
Principal balance of convertible notes
Entity Address, State or Province
Payroll tax credit.
Payroll Tax Credit
Payroll tax credit
Mergers and Aquisitions Abstract
Mergers and Aquisitions [Abstract]
Issuance of common stock to Amgen at fair value
Stock Issued During Period, Value, Conversion of Convertible Securities
Conversion of convertible preferred stock to common stock in connection with the Merger, Value
Line of Credit Facility, Remaining Borrowing Capacity
Line of credit remaining borrowing capacity
Collaboration agreement contingent payment.
Collaboration Agreement Contingent Payment
Collaboration agreement, contingent payment
Investment, Name [Domain]
Financial Liabilities Fair Value Disclosure
Fair value of warrants issued
Total
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive income (loss)
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Short-term investments, Unrealized Gains
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses
Common Stock, Capital Shares Reserved for Future Issuance
Common stock capital shares reserved for future issuance
Share based awards, common stock reserved for issuance
Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements
Dilutive securities
Class of Warrant or Right [Domain]
Geographical [Axis]
Reserved for future issuance under two thousand and seventeen stock plan.
Reserved For Future Issuance Under Two Thousand And Seventeen Stock Plan [Member]
Shares reserved for future issuance under the 2017 Stock Incentive Plan [Member]
Business Combination, Transaction Cost, Excluding Separately Recognized Transaction
Transaction Costs
Conversion of Stock, Shares Converted
Conversion of Stock, Shares Converted
Proceeds from Sale of Equity Method Investments
Proceeds from sale of equity method investments
Stock Issued During Period Value to Homology Shareholders Reverse Recapitalization
Stock Issued During Period Value to Homology Shareholders Reverse Recapitalization
Issuance of common stock to Homology shareholders in reverse recapitalization, Value
State and local income taxes, net of federal income tax effect
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-Based Compensation Expense
Other
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock from option exercises
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Income (Loss)
Schedule of Components of Net Deffered Income Taxes
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Increase (Decrease) in Notes Payable, Current
Gain on conversion of the Convertible Notes
Increase (Decrease) in Notes Payable, Current, Total
Collaborative Arrangement Disclosure [Text Block]
Agreements with Horizon
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive income (loss):
Subsequent Event [Member]
Subsequent Event [Member]
Marketable Securities, Policy [Policy Text Block]
Short-Term Investments
Facilities IT And Insurance
Facilities IT And Insurance
Facilities, IT and insurance
Upon the conversion of authorized series b redeemable convertible preferred stock.
Upon The Conversion Of Authorized Series B Redeemable Convertible Preferred Stock [Member]
Shares reserved upon the conversion of authorized Series B preferred stock [Member]
Issuance of Common Stocks from RSU Vesting
Issuance of Common Stocks from RSU Vesting
Issuance Of Common Stocks From Rsu Vesting, Shares
Property, Plant and Equipment [Abstract]
Deferred Tax Assets, Tax Credit Carryforwards, Research
Capitalized R&D expenditures
Loss before provision for income taxes
Income (Loss) Before Provision For Income Taxes
Income (loss) before provision for income taxes.
Total income (loss) before income taxes
Other Assets, Noncurrent
Other noncurrent assets
Total other noncurrent assets
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Unamortized debt discount and issuance costs
Fair Value Measurement Inputs and Valuation Techniques [Table]
Tranche one milestone.
Tranche One Milestone [Member]
Tranche One Milestone [Member]
Tranche One [Member]
Measurement Input, Expected Term [Member]
Expected Term (years) [Member]
Antidilutive Securities [Axis]
Warrant, Exercise Price, Decrease
Warrant, Exercise Price, Decrease
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested and expected to vest
Income Tax Paid, Foreign, after Refund Received
Income Tax Paid, Foreign, after Refund Received, Total
Foreign
Interest Expense, Debt
Interest expense
Interest expenses on convertible debt
Temporary equity dividend rate.
Temporary Equity Dividend Rate
Temporary equity dividend rate
Restricted cash and cash equivalents non current.
Restricted Cash And Cash Equivalents Non Current [Member]
Restricted Cash And Cash Equivalents Non Current [Member]
Domestic state and local income taxes [Member]
State and Local Jurisdiction [Member]
Related Party Transaction [Axis]
AOCI Attributable to Parent [Member]
Issuance of Common Stock During Period Pre-Closing Net of Issuance Costs
Issuance of Common Stock During Period Pre-Closing Net of Issuance Costs
Issuance of common stock in the pre-closing financing, Value
Series a redeemable preferred stock.
Series A Redeemable Preferred Stock [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Nature of business.
Nature Of Business [Table]
Convertible Debt, Current
Convertible notes
Preferred stock, $0.0001 par value; 10,000,000 shares authorized, no shares issued and outstanding at December 31, 2025 and December 31, 2024
Preferred Stock, Value, Issued
Operating lease assets lessee [Abstract].
Operating Lease Assets Lessee [Abstract]
Assets:
Minimum [Member]
Minimum [Member]
Financial Instrument [Axis]
Assets, Current [Abstract]
Current assets:
Gain (Loss) on Sale of Assets and Asset Impairment Charges
Gain on sale of asset
Gain on sale of asset
Fair Value, Inputs, Level 3 [Member]
Significant Other Unobservable Inputs (Level 3) [Member]
percentage of sublicense fees.
Percentage Of Sublicense Fees
Percentage of sublicense fees
Proceeds from Long-Term Lines of Credit
Proceeds from long term line of credit
Proceeds from borrowings under loan and security agreement
Segment Reporting [Abstract]
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Financial Assets And Liabilities Measured At Fair Value On A Recurring Basis
Disclosure in tabular form of amounts reported in the balance sheet in respect of operating lease assets and corresponding liabilities [Table Text Block].
Disclosure In Tabular Form Of Amounts Reported In The Balance Sheet In Respect Of Operating Lease Assets And Corresponding Liabilities [Table Text Block]
Schedule of Amounts Reported In The Balance Sheet In Respect Of Operating Lease Assets And Corresponding Liabilities
Common Stock And Pre-Funded Warrants [Member]
Common Stock And Pre-Funded Warrants [Member]
Common Stock And Pre-Funded Warrants [Member]
Liabilities, Current [Abstract]
Current liabilities:
Future minimum lease payment due under this sublease
Future minimum lease payment due under this sublease
Future minimum lease payment due under this sublease
Disclosure in tabular form of venture debt.
Disclosure In Tabular Form Of Venture Debt [Table]
Related Party Transactions [Abstract]
Shares, Outstanding
Ending balance, Shares
Beginning balance, Shares
Operating Loss Carryforwards
Net operating loss carryforwards
Restricted Cash and Cash Equivalent
Restricted cash and cash equivalents
Restricted Cash and Cash Equivalents, Total
Non-cash revenue from settlement of customer refund liability
Non-Cash Revenue From Settlement Of Customer Refund Liability
Non-Cash Revenue From Settlement Of Customer Refund Liability
Commitments and Contingencies
Commitments and contingencies (Note 11)
Lessee, Leases [Policy Text Block]
Leases
Development Milestone Payment Payable
Development Milestone Payment Payable
Development Milestone Payment Payable
General and Administrative Expense [Member]
General and Administrative [Member]
Operating Lease, Liability
Total
Total operating lease liabilities
Total lease liability
Series b redeemable convertible preferred stock.
Series B Redeemable Convertible Preferred Stock [Member]
Series B Redeemable Convertible Preferred Stock [Member]
Series B Redeemable Convertible Preferred Stock [Member]
Auditor Firm ID
Debt Instrument, Basis Spread on Variable Rate
Debt instrument variable interest spread
Stockholders' Equity, Reverse Stock Split
Stockholders' equity, reverse stock split
Forecast [Member]
Personnel Related and Consulting [Member]
Personnel Related and Consulting [Member]
Personnel Related and Consulting [Member]
Amount of refund liability.
Amount Of Refund Liability
Refund liability
Fair Value Measurement Inputs and Valuation Techniques [Abstract]
Cash, Cash Equivalent, and Short-Term Investment [Text Block]
Short-Term Investments
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Investment Maturity Term
Investment Maturity Term
Contractual maturity date of investments
Interest Income (Expense), Operating
Interest Income (Expense), Operating, Total
Interest (income) expense, net
Capital Expenditures Incurred but Not yet Paid
Interest payments on venture debt
Share-Based Payment Arrangement, Recognized Amount [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic
Weighted-average common shares - basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted-average common shares outstanding-basic
Scenario [Axis]
Document Information [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Schedule of Reconciliation Federal Statutory Income Tax Rate to Effective Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Segments [Axis]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Valuation Allowance [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures
Stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures, Total
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Deferred tax assets:
Deferred Tax Assets, Net [Abstract]
Disclousre of prepaid expenses other current assets and other noncurrent assets text block.
Disclousre Of Prepaid Expenses Other Current Assets and Other Noncurrent Assets [Text Block]
Prepaid Expenses, Other Current Assets and Other Noncurrent Assets
Subsequent Events [Text Block]
Subsequent Events
Long-Term Debt
Carrying amount
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Variable Rate [Domain]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Changes in valuation allowances
Equity, Attributable to Parent
Ending balance
Beginning balance
Total stockholders' equity (deficit)
Preferred Stock, Par or Stated Value Per Share
Preferred stock par value per share
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Statement of Stockholders' Equity [Abstract]
Equity Method Investments
Equity method investments
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Equity Method Investment [Table]
Business Contact [Member]
Leasehold Improvements [Member]
Leasehold improvements [Member]
Recognized Remaining Vesting Terms
Recognized Remaining Vesting Terms
Recognized Remaining Vesting Terms
Fair Value Disclosures [Text Block]
Fair Value Measurements
Accounting policies.
Accounting Policies [Table]
Disclosure in tabular form of common stock shares reserved for future issuance.
Disclosure In Tabular Form Of Common Stock Shares Reserved For Future Issuance [Table]
Revenue used to determine transaction price.
Revenue Used To Determine Transaction Price
Transaction price to be determined
Number of common stock underlying shares
Number of Common Stock Underlying Shares
Number of Common Stock Underlying Shares
Accrued research and development expenses current.
Accrued Research And Development Expenses Current
Accrued external research and development
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Assumed in Reverse Recapitalization
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Assumed in Reverse Recapitalization
Number of shares, Assumed in reverse recapitalization
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Expenses and Other Current Liabilities
Debt Instrument, Name [Domain]
Debt Instrument, Collateral Amount
Debt instrument collateral given
Other Assets, Current
Other
Income (Loss) from Equity Method Investments
Loss from equity method investment
Loss from equity method investment
Series a redeemable convertible preferred stock.
Series A Redeemable Convertible Preferred Stock [Member]
Tax credit carryforwards expiration year.
Tax Credit Carryforwards Expiration Year
Tax credit carryforwards expiration year
Two thousand and twenty and two thousand and twenty three term a loan.
Two Thousand And Twenty And Two Thousand And Twenty Three Term A Loan [Member]
Two Thousand And Twenty And Two Thousand And Twenty Three Term A Loan [Member]
Deferred Costs, Noncurrent
Deferred transaction costs
Prepaid Expense and Other Assets, Noncurrent [Abstract]
Segment Reporting, Other Segment Item, Amount
Other segment items
Plan Name [Domain]
Revenue, Performance Obligation Satisfied over Time [Abstract]
Interest Expense, Operating and Nonoperating
Interest expenses
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Temporary Equity, Including Noncontrolling Interest
Ending balance
Beginning balance
Equity Method Investment, Ownership Percentage
Equity method investment, ownership, percentage
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Accruals and reserves
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Loss Reserves
Impairment, Long-Lived Asset, Held-for-Use
Impairment, long-lived asset, held-for-use
Current State and Local Tax Expense (Benefit)
Current, State
Business Description and Basis of Presentation [Text Block]
Nature of the Business
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Indirect Research and Development [Member]
Indirect Research and Development [Member]
Indirect Research and Development [Member]
Warrants and Rights Outstanding
Class of Warrant or Right, Outstanding
Deferred Charges, Policy [Policy Text Block]
Deferred Transaction Costs
CVR Liability
CVR Liability
CVR liability
Sales based milestone.
Sales Based Milestone [Member]
Sales-based milestone
Issuance of common stock to Amgen at fair value
Issuance of common stock to Amgen at fair value
Issuance of common stock to Amgen Value
Issuance of common stock to Amgen Value
Issuance of common stock to Amgen
Related and Nonrelated Parties [Axis]
Asset Acquisition [Text Block]
Convertible Debt, Fair Value Disclosures
Convertible debt, fair value disclosures
Convertible debt at fair value
Foreign Tax Jurisdiction [Member]
Foreign income taxes [Member]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Area of Real Estate Property
Office space leased
Entity Address, City or Town
Business Combination, Achieved in Stages, Preacquisition and Acquired Equity Interests in Acquiree, Percentage
Outstanding common stock of the combined company
Cash, FDIC Insured Amount
Cash FDIC insured amount
Number of Reportable Segments
Number of Reportable Segments
Security Exchange Name
Stockholders' Equity Note, Spinoff Transaction
Reverse recapitalization transaction costs
Long-Term Debt, Gross
Principal amount of term loans
Two thousand seventeen stock option and grant plan.
Two Thousand Seventeen Stock Option and Grant Plan [Member]
2017 Stock Option and Grant Plan [Member]
Before thirty first of march two thousand and twenty six.
Before Thirty First Of March Two Thousand And Twenty Six [Member]
Before Thirty First Of March Two Thousand And Twenty Six [Member]
Property, Plant and Equipment, Gross
Total property and equipment
Installment sale
Deferred Tax Liabilities Installment Sale
Deferred Tax Liabilities Installment Sale
Summary of prepaid expenses and other current assets table text block.
Summary Of Prepaid Expenses And Other Current Assets [Table Text Block]
Summary of Prepaid Expenses and Other Current Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Number of shares, Vested and expected to vest
Venture debt two thousand twenty and two thousand and twenty three term a loan.
Venture Debt Two Thousand Twenty And Two Thousand And Twenty Three Term A Loan [Member]
Payment Of Reverse Recapitalization Transaction Costs
Payment Of Reverse Recapitalization Transaction Costs
Payment of reverse recapitalization transaction costs
License agreement with the university of colorado.
License Agreement With The University Of Colorado [Member]
Period.
Period [Axis]
Disclosure of information about merger and acquisition.
Merger and Acquisition [Table]
Measurement Input Type [Domain]
Antidilutive Securities, Name [Domain]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign tax differences
ADX Zero Nine Seven [Member]
ADX Zero Nine Seven [Member]
ADX-097 [Member]
Temporary Equity, Dividends, Adjustment
Temporary equity, dividends, adjustment
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents, restricted cash and restricted cash equivalents at end of period
Cash, cash equivalents, restricted cash and restricted cash equivalents at beginning of period
Total cash, cash equivalents, restricted cash and restricted cash equivalents
Accounts Payable and Accrued Liabilities
Accounts payable and accrued liabilities
Accounts Payable and Accrued Liabilities, Total
Accounts payable and accrued liabilities
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Measurement Basis [Axis]
Statistical Measurement [Domain]
Class of Warrant or Right, Exercise Price of Warrants or Rights
Class of warrants or rights exercise price per share
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Total stock-based compensation expense
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table Text Block]
Summary of the transaction price allocated to each performance obligation
Document Period End Date
AA phase two research services.
AA Phase Two Research Services [Member]
AA phase 2 research services
Equity Method Investments and Joint Ventures [Abstract]
Equity Method Investment [Abstarct]
Issuance of Common Stock During Period Pre-Closing Financing, Net of Issuance Costs
Issuance of Common Stock During Period Pre-Closing Financing, Net of Issuance Costs
Issuance of common stock in the pre-closing financing, Shares
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
ICFR Auditor Attestation Flag
Investments Disclosure Abstract
Investments Disclosure Abstract
Investments Disclosure [Abstract]
Period of obligation to pay royalties.
Period Of Obligation To Pay Royalties
Period of obligation to pay royalties
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of Shares, Exercisable
Line of Credit Facility, Commitment Fee Percentage
Line of credit facility commitment fee percentage
Gain (Loss) on Disposition of Property Plant Equipment
Loss on disposal of property and equipment
Loan and security fourth amendment agreement with silicon valley bank.
Loan And Security Fourth Amendment Agreement With Silicon Valley Bank [Member]
Loan And Security Fourth Amendment Agreement With Silicon Valley Bank [Member]
Temporary Equity Stock Issuance Costs
Temporary equity stock issuance costs.
Temporary equity stock issuance costs
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted stock units
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Collaboration agreement contingent payment payable excess of cash received.
Collaboration Agreement Contingent Payment Payable Excess Of Cash Received
Collaboration agreement, contingent payment payable excess of cash received
Operating lease liabilities lessee [Abstract].
Operating Lease Liabilities Lessee [Abstract]
Liabilities:
Stock Issued During Period, Shares, Purchase of Assets
Stock issued during period shares purchase of assets
Revenue [Policy Text Block]
Revenue Recognition
Antidilutive Security, Excluded EPS Calculation [Table]
Lessee operating lease not yet commenced increase in percentage of base rent.
Lessee Operating Lease Not Yet Commenced Increase In Percentage Of Base Rent
Percentage increase in initial annual base rent per square foot.
Long term debt balloon payment percentage.
Long Term Debt Balloon Payment Percentage
Long term debt balloon payment percentage
Class of Stock [Axis]
Class of Stock [Axis]
Deferred Tax Liabilities, Net
Total deferred tax liabilities
Total deferred tax liabilities
Short Term Investments Acquired In reverse recapitalization
Short Term Investments Acquired In reverse recapitalization
Short Term Investments Acquired In reverse recapitalization
Business combination shares conversion into rights to purchase common stock.
Business Combination Shares Conversion Into Rights To Purchase Common Stock
Business combination shares conversion into rights to purchase common stock
Seventh amendment to the loan agreement.
Seventh Amendment To The Loan Agreement [Member]
Seventh Amendment To The Loan Agreement [Member]
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Realized gains and losses on available-for-sale securities
Debt Securities, Available-for-Sale, Realized Gain (Loss), Total
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Restricted cash non current.
Restricted Cash Non Current [Member]
Restricted Cash Non Current [Member]
Liabilities
Total liabilities
Financial Instruments [Domain]
Tabular disclosure of recapitalization of assets and liabilities.
Schedule of Recapitalization of Assets and Liabilities [Table Text Block]
Schedule of Recapitalization of Assets and Liabilities
Upon the conversion of authorized series a redeemable convertible preferred stock.
Upon The Conversion Of Authorized Series A Redeemable Convertible Preferred Stock [Member]
Shares reserved upon the conversion of authorized Series A preferred stock [Member]
Two thousand and twenty three term a loan advance.
Two Thousand And Twenty Three Term A Loan Advance [Member]
Two Thousand And Twenty Three Term A Loan Advance [Member]
Equity Method Investments [Policy Text Block]
Investments in Equity Securities
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Foreign tax effect
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Conversion of temporary equity into permanent equity shares.
Conversion Of Temporary Equity Into Permanent Equity Shares
Conversion of temporary equity into permanent equity shares
Scenario two member.
Scenario Two [Member]
Scenario two [Member]
OptionRepricing 1
OptionRepricing 1
Option Repricing
Restricted Stock [Member]
Shares reserved for vesting of restricted stock units [Member]
CVR liability revaluation
Effective Income Tax Rate Reconciliation CVR Liability Revaluation Income Taxes Percent
Effective Income Tax Rate Reconciliation CVR Liability Revaluation Income Taxes Percent
Variable Rate [Axis]
Prepaid Expense and Other Assets, Current [Abstract]
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average common shares - diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted-average common shares outstanding-diluted
Entity File Number
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Change in unrealized gain (loss) on available for sale securities, net
Share Based Compensation Arrangement By Share Based Payment Award Purchase Price Of Common Stock Through Payroll Deductions Percentage
Share Based Compensation Arrangement By Share Based Payment Award Purchase Price Of Common Stock Through Payroll Deductions Percentage
Purchase of common stock through payroll deductions expressed in percentage of fair market value
Cover [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected stock price volatility range, minimum
Measurement Input Type [Axis]
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Taxes Payable, Current
Accrued taxes payable
Scenario one member.
Scenario One [Member]
Scenario one [Member]
Summary of Valuation Allowance [Table Text Block]
Summary of Changes in The Valuation Allowance
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest
Loss before income taxes
Income (loss) before provision for income taxes and loss from equity method investment
Debt instrument conversion price percentage.
Debt Instrument Conversion Price Percentage
Debt instrument conversion price percentage
Collaborative arrangement milestone payments.
Collaborative Arrangement Milestone Payments
Collaboration agreement, Aggregate amount of sales milestone
Scenario [Domain]
US Treasury Securities [Member]
US Treasury securities
License agreement with bristol mayers equib company.
License Agreement With Bristol Mayers Equib Company [Member]
License Agreement With Bristol Mayers Equib Company [Member]
Segment Reporting
Segment Reporting Disclosure [Text Block]
General and Administrative Expense
General and administrative
AD phase two research services.
AD phase two research services [Member]
AD phase 2 research services
Increase In Number Of Shares Reserved For Issuance Percent Of Common Stock Outstanding
Increase In Number Of Shares Reserved For Issuance Percent Of Common Stock Outstanding
Increase in number of shares reserved for issuance, percent of common stock outstanding
Temporary Equity, Liquidation Preference
Preferred stock liquidation preference
Number of directors entitled to be elected.
Number Of Directors Entitled To Be Elected
Number of directors entitled to be elected
Subsequent Event [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Shares issued during period
Debt Instrument, Convertible, Conversion Price
Debt instrument conversion price per share
Loan and security fifth amendment agreement with silicon valley bank.
Loan And Security Fifth Amendment Agreement With Silicon Valley Bank [Member]
Loan And Security Fifth Amendment Agreement With Silicon Valley Bank [Member]
Fixed assets
Deferred Tax Liabilities, Other Fixed Assets
Deferred Tax Liabilities, Other Fixed Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted- Average Exercise Price, Vested and expected to vest
Reserved For Future Issuance Under Two Thousand And Twenty Four Employee Stock Purchase Plan [Member]
Reserved For Future Issuance Under Two Thousand And Twenty Four Employee Stock Purchase Plan [Member]
Shares reserved for future issuance under the 2024 Employee Stock Purchase Plan
Property, Plant and Equipment, Useful Life
Estimated Useful Life (Years)
Phase.
Phase [Domain]
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Maturities of Operating Lease Liabilities
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Before thirty first of march two thousand and twenty four.
Before Thirty First Of March Two Thousand And Twenty Four [Member]
Before Thirty First Of March Two Thousand And Twenty Four [Member]
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of convertible preferred stock to common stock in connection with the Merge, Share
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other
Total current
Total Current Expense Benifit
Total Current Expense Benifit
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Share based awards, vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate range, Minimum
Income (Loss) from Continuing Operations before Income Taxes, Domestic
United States
Amount
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Depreciation
Depreciation expense
Fair value of interest expenses.
Fair value Of Interest Expenses
Fair value Of Interest Expenses
Milestone receivable upon the earlier of achievement of the first milestone
Other Receivables, Net, Current
Other Receivables, Net, Current, Total
Loan and security agreement with silicon valley bank.
Loan And Security Agreement With Silicon Valley Bank [Member]
Loan And Security Agreement With Silicon Valley Bank [Member]
Purchase of common share
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock shares outstanding
Operating Lease, Liability, Current
Operating lease liability, current
Lease liability, current portion
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, Remaining Performance Obligation, Amount
Transaction Price
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Share-Based Payment Arrangement, Additional Disclosure [Abstract]
Net deferred tax assets
Deferred Tax Assets, Net
Short-Term Investments
Short-term investments
Short-Term Investments, Total
Operating Expenses
Total operating expenses
Off-Balance-Sheet Credit Exposure, Policy [Policy Text Block]
Off Balance Sheet Risk
Research and Development Expense
Research and development
Research and development expenses
Total segment and consolidated research and development expenses
Total segment and consolidated research and development expenses
Convertible Preferred Stock [Member]
Schedule of Components of Income Tax Expense
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Current liabilities.
Current Liabilities [Member]
Current Liabilities [Member]
Statement of Cash Flows [Abstract]
Current Federal Tax Expense (Benefit)
Current, Federal
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Loan and security third amendment agreement with silicon valley bank.
Loan And Security Third Amendment Agreement With Silicon Valley Bank [Member]
Loan And Security Third Amendment Agreement With Silicon Valley Bank [Member]
Excess tax benefits on share-based payments
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Equity [Text Block]
Common Stock
Earnings Per Share [Text Block]
Net Income (Loss) per Share
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Measurement Input, Expected Dividend Rate [Member]
Required market rates of return [Member]
Computer Equipment [Member]
Computer equipment [Member]
Cybersecurity Risk Management Processes Integrated [Text Block]
Net income (loss)
Net income (loss)
Net income (loss)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding Ending Balance
Aggregate Intrinsic Value, Outstanding Beginning Balance
Aggregate Intrinsic Value, Outstanding Ending Balance
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid
Long term debt balloon payment
Operating Lease, Cost
Fixed lease costs
Change in Fair Value Of Convertible Notes
Change in Fair Value Of Convertible Notes
Change in fair value of convertible notes
Change in fair value of convertible notes
Warrants and Rights Outstanding, Term
Class of warrants or rights term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate
Estimated aggregate proceeds from equity.
Estimated Aggregate Proceeds From Equity
Estimated aggregate proceeds from equity
Assets [Abstract]
Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate range
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Amortization of Debt Issuance Costs and Discounts
Amortization of debt discount and issuance costs
Document Fiscal Year Focus
Document Fiscal Year Focus
Debt Instrument, Measurement Input
Debt instrument, measurement input
Debt Conversion, Converted Instrument, Shares Issued
Debt instrument converted into equity number of shares issued
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Accounts Payable, Current
Accounts payable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Fair value of options vested
Schedule of Income (Loss) Before Provision For Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Research and Development Expense [Member]
Research and Development [Member]
Other Operating Segment [Member]
Deferred Tax Liabilities, Accrued Expense
Deferred Tax Liabilities, Accrued Expense
Accrued expenses
Increase (Decrease) in Other Noncurrent Assets
Other noncurrent assets
Recognized
Business Combination, Separately Recognized Transactions, Revenues and Gains Recognized
Proceeds from sale of asset
Proceeds from Sale of Productive Assets
Proceeds from Sale of Productive Assets, Total
Deferred Federal Income Tax Expense (Benefit)
Deferred, Federal
Accrued expenses and other current liabilities disclosure.
Accrued Expenses And Other Current Liabilities Disclosure [Text Block]
Accrued Expenses and Other Current Liabilities
Research Tax Credit Carryforward [Member]
Before thirty first of march two thousand and twenty five.
Before Thirty First Of March Two Thousand And Twenty Five [Member]
Before Thirty First Of March Two Thousand And Twenty Five [Member]
Total Segment Net Loss
Total Segment Net Loss
Total segment net income (loss)
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Measurements
Other Liabilities
Due to related parties
Temporary Equity Disclosure [Abstract]
Proceeds from Stock Options Exercised
Proceeds from exercise of common stock options
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Prepaid Expense
Prepaid expenses
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Sale of Stock, Consideration Received on Transaction
Reverse recapitalization transaction costs
Net Income (Loss) Available to Common Stockholders, Basic
Net income (loss) attributable to common stockholders- basic
Net Income (Loss) Available to Common Stockholders, Basic, Total
Net income (loss)-basic
Effective Income Tax Rate Reconciliation [Line Items]
Phase.
Phase [Axis]
Income Tax Description
Income Tax Examination, Description
Debt Instrument [Axis]
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Share-Based Payment Arrangement [Abstract]
Assets, Fair Value Disclosure
Assets, Fair Value Disclosure, Total
Development and Regulatory Milestones Receivable
Development and Regulatory Milestones Receivable
Development and regulatory milestones
Equity Method Investments and Joint Ventures Disclosure [Text Block]
Investment in Equity Securities
Revenues
Collaboration arrangement revenue
Revenues, Total
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by investing activities
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Stock Issued During Period, Value, Conversion of Units
Issuance of common stock for conversion of Convertible Notes, Value
Series a two redeemable convertible preferred stock.
Series A Two Redeemable Convertible Preferred Stock [Member]
Series A Two Redeemable Convertible Preferred Stock [Member]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Excess tax benefits on share-based payments
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted- Average Exercise Price, Forfeited
Money Market Funds [Member]
Money Market Funds [Member]
Related and Nonrelated Parties [Domain]
Income Tax Disclosure [Text Block]
Income Taxes
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Temporary Equity, Shares Issued
Preferred stock shares issued
Equity investment
Equity Method Investment, Aggregate Cost
Equity investment
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Assumed in reverse recapitalization, Weighted Average Exercise Price
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Assumed in reverse recapitalization, Weighted Average Exercise Price
Weighted- Average Exercise Price, Assumed in reverse recapitalization
Received loan agreement
Recived Loan Agreement
Recived Loan Agreement
Document Information [Table]
Other Liabilities, Noncurrent
Other noncurrent liabilities
Long term debt percentage bearing annual prime rate
Long Term Debt Percentage Bearing Annualy Prime Rate
Long Term Debt Percentage Bearing Annualy Prime Rate
Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals
Future minimum lease payments due under this sublease
Consolidated Entities [Axis]
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Property, Plant and Equipment [Table Text Block]
Schedule of Property Plant and Equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted- Average Exercise Price, Outstanding at Ending Balance
Weighted- Average Exercise Price, Outstanding at Beginning Balance
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Net operating loss carryforwards expiration year.
Net Operating Loss Carry forwards Expiration Year
Net operating loss carryforwards, expiration year
Unrecognized Tax Benefits
Unrecognized tax benefits
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Accrued expenses and other current liabilities
Non-cash expenses [Member]
Non-cash expenses [Member]
Schedule of Income Taxes Paid [Table Text Block]
Schedule of Income Taxes Paid [Table Text Block]
Schedule of Income Taxes Paid
Measurement Frequency [Domain]
Measurement Frequency
Statement of Income Location, Balance [Axis]
Trading Symbol
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Related Party Transaction [Table]
Accrued Expenses And Other Liabilities Current
Accrued Expenses And Other Liabilities Current
Accrued expenses and other current liabilities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate range, Maximum
Convertible Notes [Member]
Convertible Notes [Member]
Convertible Notes [Member]
Subsequent Event Type [Axis]
Percentage of consolidated cash to be maintained with the lender.
Percentage Of Consolidated Cash To Be Maintained With The Lender
Percentage of consolidated cash to be maintained with the lender
Employee-related Liabilities, Current
Accrued compensation and related expenses
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Related Party Transaction, Purchases from Related Party
Related party transaction expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years) range
Fair Value, Recurring [Member]
Fair Value, Measurements, Recurring [Member]
Schedule of Equity Method Investments [Line Items]
Lessee, Operating Lease, Liability, to be Paid, Total
Total minimum lease payments
Total minimum lease payments
Stock-based compensation expense
EffectiveIncomeTaxRateReconciliationStockBasedCompensationExpensePercent
EffectiveIncomeTaxRateReconciliationStockBasedCompensationExpensePercent
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less imputed interest
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research and development tax credits
Research and development tax credits
Equity Components [Axis]
Line of Credit, Current
Venture debt, current portion
Line of credit facility outstanding current
Nonoperating Income (Expense)
Total other income (expense), net
Prepaid external research and development current.
Prepaid External Research And Development Current
Prepaid external research and development
Equity Component [Domain]
Asset Class [Axis]
Two Thousand Twenty Four Employee Stock Purchase Plan [Member]
Two Thousand Twenty Four Employee Stock Purchase Plan [Member]
2024 Employee Stock Purchase Plan [Member]
Address Type [Domain]
Document Annual Report
Prepaid Expense Other, Noncurrent
Other
Business Combination [Axis]
Long-Term Debt, Percentage Bearing Fixed Interest, Percentage Rate
Convertible debt interest rate percentage
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Vesting of restricted stock, Shares
Event.
Event [Domain]
Event [Domain]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table]
Discovery and Other [Member]
Discovery and Other [Member]
Discovery and Other [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Share based awards, maximum contractual term
Issuance of Common Stock to Amgen Shares
Issuance of Common Stock to Amgen Shares
Issuance of common stock to Amgen, Shares
Statement of Comprehensive Income [Abstract]
Equity Method Investment, Other-than-Temporary Impairment
Impairment charge
Maximum [Member]
Maximum [Member]
Scenario three member.
Scenario Three [Member]
Scenario three [Member]
Entity Addresses, Address Type [Axis]
Accrued professional fees and other accrued liabilities current.
Accrued Professional Fees And Other Accrued Liabilities Current
Accrued professional services and other
Statistical Measurement [Axis]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted- Average Exercise Price, Exercised
Prepaid Expense, Current
Prepaid expenses
Other G&A expenses [Member]
Other G&A expenses
Common Stock, Value, Issued
Common stock, $0.0001 par value; 400,000,000 shares authorized, 12,858,047 and 12,197,615 shares issued and outstanding at December 31, 2025 2024, respectively
Unrestricted and unencumbered cash percentage to be maintained.
Unrestricted And Unencumbered Cash Percentage To Be Maintained
Unrestricted and unencumbered cash percentage to be maintained
Property, Plant and Equipment [Member]
Property, Plant and Equipment [Member]
Net Income (Loss) Available to Common Stockholders, Diluted, Total
Net income (loss) attributable to common stockholders, Diluted
Net Income (Loss) Available to Common Stockholders, Diluted, Total
Net income (loss)-diluted
Line of Credit Facility, Expiration Date
Line of credit facility expiration date
Development and sales milestone payment payable.
Development And Sales Milestone Payment Payable
Development and sales milestone payment payable
Increase (Decrease) in Asset, Held-for-Sale
Transaction as an asset sale
Income Tax Disclosure [Line Items]
Cash and Cash Equivalents [Abstract]
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Equipment [Member]
Lab equipment [Member]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward [Axis]
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State income taxes, net of federal benefit
Indirect research and development expense
Indirect Research and Development Expense
Indirect Research and Development Expense
Gain/loss on convertible note conversion
Effective Income Tax Rate Reconciliation Gain loss On Convertible Note Conversion
Effective Income Tax Rate Reconciliation Gain loss On Convertible Note Conversion
Current liabilities lessee [Abstract].
Current Liabilities Lessee [Abstract]
Current:
Entity Public Float
Income Taxes Paid, Net [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected stock price volatility range
Preferred Stock, Shares Authorized
Preferred stock shares authorized
Proceeds from Collaborators
Received amount from Horizon
Mergers, Acquisitions and Dispositions Disclosures [Text Block]
Accounting for the Merger
Cash, Cash Equivalent, and Investment [Table Text Block]
Summary of Short Term Investments
Related Party Transaction [Line Items]
Disclosure in tabular form of venture debt.
Disclosure in tabular form of venture debt [Line Items]
Business Combination [Table]
Entity Registrant Name
Debt Disclosure [Text Block]
Debt
Capitalized Intangible Assets
Capitalized Intangible Assets
Capitalized intangible assets
Period.
Period [Domain]
Non current liabilities lessee [Abstract].
Non Current Liabilities Lessee [Abstract]
Noncurrent:
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Short-term investments, Unrealized Losses
Short-term investments, Unrealized Losses
Proceeds from Sale of Short-Term Investments
Maturities of short-term investments
Entity Voluntary Filers
Royalty as a percentage of net sales.
Royalty As A Percentage Of Net Sales
Royalty as a percentage of sales
Disclosure in tabular form of common stock shares reserved for future issuance.
Disclosure In Tabular Form Of Common Stock Shares Reserved For Future Issuance [Table Text Block]
Schedule of Shares of Common Stock for Future Issuance
Other Nonoperating Income (Expense)
Other income (expense), net
Other Nonoperating Income (Expense), Total
Other income (expense)
Additional Paid in Capital
Additional paid-in capital
Deferred State
Deferred State and Local Income Tax Expense (Benefit)
Disclosure in entirety of temporary equity.
Disclosure In Entirety Of Temporary Equity
Convertible Preferred Stock
Line of Credit Facility, Frequency of Payments
Line of credit facility frequency of payments
Subsequent Events [Abstract]
Tranche three milestone.
Tranche Three Milestone [Member]
Tranche Three [Member]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Consolidated Entities [Domain]
Total income tax expense
Effective income tax rate
Income Tax Expense (Benefit)
Provision for tax expense (benefit)
Provision for income taxes
Measurement Frequency [Axis]
Measurement Frequency
Eighth Amendment To The Loan Agreement Member
Eighth Amendment to the Loan Agreement [Member]
Property plant and equipment useful life 1.
Property Plant And Equipment Useful Life 1
Estimated Useful Life (Years)
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock in pre-closing financing
Issuance of common stock to Amgen
Stock Issued During Period Value to Homology Shareholders in Reverse Recapitalization
Stock Issued During Period Value to Homology Shareholders in Reverse Recapitalization
Issuance of common stock to Homology shareholders in reverse recapitalization, Shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Summary of Fair Value Measurement Significant Inputs
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations of Credit Risk and Significant Suppliers
Compensation Related Costs, Policy [Policy Text Block]
Stock-Based Compensation
Merger and Acquisition [Line Items]
Merger and Acquisition [Line Items]
Merger and Acquisition [Line Items]
Stock compensation and other
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Other
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer
Collaboration agreement revenue
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Temporary Equity, by Class of Stock [Table]
Assets
Net assets acquired
Total assets
Property, Plant and Equipment [Table]
State
Income Tax Paid, State and Local, after Refund Received
Income Tax Paid, State and Local, after Refund Received, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term, Exercisable
Income Statement [Abstract]
Reclassifications of Temporary to Permanent Equity
Temporary equity converted into permanent equity value
Excess of accrued right to purchase stock
Excess of accrued right to purchase stock
Excess of accrued right to purchase stock
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Unrecognized tax benefits, settlements
Deferred Income Tax Expense (Benefit)
Deferred Income Tax Expense (Benefit), Total
Current and deferred income tax expense
Stock Issued During Period, Shares, New Issues
Stock issued during the period new issues
Temporary Equity, Shares Authorized
Preferred stock shares authorized
Proceeds from Reverse Recapitalization
Proceeds from Reverse Recapitalization
Cash acquired in connection with reverse recapitalization
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Shares, Vested
Deferred Tax Assets, Operating Lease Liability
Deferred Tax Assets, Operating Lease Liability
Operating lease liability
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Net income (loss) per share-diluted
Net income (loss) per share- diluted
Schedule of Segment Reporting Information Expenses
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Collaboration agreement transaction price.
Collaboration Agreement Transaction Price
Collaboration agreement, transaction price
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Percentage
Commercial Milestones Receivable
Commercial Milestones Receivable
Commercial milestones
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
City Area Code
Two Thousand Twenty Four Stock Option and Incentive Plan [Member]
Two Thousand Twenty Four Stock Option and Incentive Plan [Member]
2024 Stock Option and Incentive Plan [Member]
Issuance Of CVR At Fair Value
Issuance Of CVR At Fair Value
Issuance of CVR at fair value
prepaid external research and development nonurrent.
prepaid external research and development nonurrent
Prepaid external research and development - long term
Auditor Name
Line of credit facility amount that may be contingently borrowed.
Line Of Credit Facility Amount That May Be Contingently Borrowed
Line of credit facility amount that may be contingently borrowed
Accrued penalties and provisions for interest
Income Tax Examination, Penalties and Interest Expense
Income Tax Examination, Penalties and Interest Expense, Total
Debt Instrument, Face Amount
Debt instrument face value
Line of Credit Facility, Maximum Borrowing Capacity
Line of credit maximum borrowing capacity
Business Combination [Line Items]
Rule 10b5-1 Arr Modified [Flag]
Rule 10b5-1 Arrangement Modified [Flag]
Rule 10b5-1 Arrangement Modified
Horizon Therapeutics Ireland DAC Member
Horizon Therapeutics Ireland DAC [Member]
Horizon Therapeutics Ireland DAC
Tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Total
Increase In Common Stock Capital Shares Reserved For Future Issuance
Increase In Common Stock Capital Shares Reserved For Future Issuance
Increase in number of shares reserved for issuance (shares)
Research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Convertible Debt, Noncurrent
Convertible notes
Loan and security second amendment agreement with silicon valley bank.
Loan And Security Second Amendment Agreement With Silicon Valley Bank [Member]
Loan And Security Second Amendment Agreement With Silicon Valley Bank [Member]
Variable Lease, Cost
Variable lease costs
Estimated aggregate proceeds from debt and equity.
Estimated Aggregate Proceeds From Debt And Equity
Estimated aggregate proceeds from debt and equity
Operating Lease, Weighted Average Remaining Lease Term
Operating lease weighted average remaining lease term
Segment Reporting Information [Line Items]
Lease Expiration Date
Lease expiration date
Lease, Cost, Total
Total lease costs
Summary of Prepaid Expenses and Other Noncurrent Assets [Table Text Block]
Summary of Prepaid Expenses and Other Noncurrent Assets [Table Text Block]
Summary of Prepaid Expenses and Other Noncurrent Assets
Long-Term Debt, Percentage Bearing Variable Interest, Percentage Rate
Long term debt variable interest rate percentage
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
Amounts due under Asset Purchase Agreement
Amount Due Under Asset Purchase Agreements
Amount Due Under Asset Purchase Agreements
Deferred Foreign
Deferred Foreign Income Tax Expense (Benefit)
Operating Income (Loss)
Income (loss) from operations
Retained Earnings [Member]
Accumulated Deficit [Member]
Contingent liability
Deferred Tax Assets, Frequent Flier Liability
Company's RSU Activity
Share-Based Compensation Arrangements by Share-Based Payment Award, Restricted Stock Units, Vested and Expected to Vest [Table Text Block]
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Line of Credit Facility, Date of First Required Payment
Line of credit facility date of first required payment
Pre-Funded Warrant [Member]
Pre-Funded Warrant [Member]
Pre-Funded Warrant [Member]
Series A Convertible Preferred Stock.
Series A Convertible Preferred Stock [Member]
Series A convertible preferred stock [Member]
Series A convertible preferred stock [Member]
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease weighted average discount rate
Operating Lease, Liability, Noncurrent
Lease liability, net of current portion
Operating lease liabilities, net of current portion
Fair Value, Inputs, Level 1 [Member]
Quoted Prices in Active Markets (Level 1) [Member]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by (used in) financing activities
Facilities, IT and other allocated costs [Member]
Facilities, IT and other allocated costs [Member]
Short-Term Debt [Line Items]
Lease, Cost [Table Text Block]
Schedule of Operating Lease Cost and Variable Lease Costs and Sub Lease Income
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Asset Acquisition [Abstract]
Auditor Location
Regulatory Milestone Payment Upon Approval
Regulatory Milestone Payment Upon Approval
Milestone Payment Based on Approval
Earnings Per Share Reconciliation [Abstract]
Numerator:
Income Tax Examination, Likelihood of Unfavorable Settlement
Income Tax Description
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of computation of diluted net loss per share attributable to common stockholders
Income Tax Jurisdiction [Domain]
Entity Interactive Data Current
Oxb Solutions [Member]
Oxb Solutions [Member]
Oxb Solutions
Statement of Income Location, Balance [Domain]
Fair Value Measurement [Domain]
Lessee, Operating Lease, Lease Not yet Commenced, Renewal Term
Lessee, operating lease, lease not yet commenced, renewal term
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Furniture and Fixtures [Member]
Furniture and fixtures [Member]
Line of credit facility aggregate amount including balloon repayment payable.
Line Of Credit Facility Aggregate Amount Including Balloon Repayment Payable
Line of credit facility aggregate amount including balloon repayment payable
Accretion (Amortization) of Discounts and Premiums, Investments
Amortization of premium on short-term investments
Amortization of premium on short-term investments
Entity Tax Identification Number
Disclosure in tabular form of venture debt.
Disclosure In Tabular Form Of Venture Debt [Table Text Block]
Summary of Long-term Debt Balance
Agreement.
Agreement [Axis]
Agreement [Axis]
Business Combination, Contingent Consideration, Asset, Current
Business combination, intial consideration
Other G&A expenses
Other G&A expenses
Local Phone Number
Related Party Transaction [Domain]
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognised compensation cost
Temporary equity conversion price per share.
Temporary Equity Conversion Price Per Share
Temporary equity conversion price per share
Auditor Opinion [Text Block]
Auditor Opinion
Payment To Horizon
Payment to Horizon
Payment to horizon
Accounting Policies [Abstract]
Common Stock, Number of Shares, Par Value and Other Disclosure [Abstract]
Two thousand and twenty term a loan advance.
Two Thousand And Twenty Term A Loan Advance [Member]
Two Thousand And Twenty Term A Loan Advance [Member]
Sixth amendment agreement with silicon valley bank.
Sixth Amendment Agreement With Silicon Valley Bank [Member]
Sixth Amendment Agreement With Silicon Valley Bank [Member]
Long-Term Line of Credit, Noncurrent
Venture debt, net of current portion
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
Class of Stock [Domain]
Class of Stock [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Share based awards, shares available for future grant
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognised compensation cost, recognition period
Self Insurance Reserve
Executive insurance reserve
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term, Vested and expected to vest
Tax Credit Carryforward, Name [Domain]
Leasehold Improvements
Leasehold Improvements